Clinical Experience with Tolbutamide

Clinical Experience with Aureomycin.

Symptomatic hyponatraemia associated with tolbutamide therapy.

A case of hyponatraemic coma occurring in a patient with diabetes mellitus treated with tolbutamide is described. Although chlorpropamide is known to cause water retention in some circumstances, this is a less well recognized complication of tolbutamide therapy.

The Effects of Tolbutamide

The effects of chronic tolbutamide treatment were examined in a diabetic animal model in which abnormal myocardial function and composition have previously been demonstrated. Eight diabetic dogs were given tolbutamide 250 mg/day orally and compared with seven untreated diabetics, five healthy dogs receiving tolbutamide, and eight normal controls. After one year, resting hemodynamic studies in t...

Clinical Experience with Surital Sodium*

StrmWAL sodium was introduced to the Canadian market this year as a proven intravenous anaesthetic agent. For thls reaso-ff~it was f~lt timely to discuss the place of Surital m present day clinical anaesthesia. It is gratifying to note that Surital has had a long and careful laboratory and clinical trial, over a period of seven years, before it was released to the open market. There have been f...

Clinical experience with pegaptanib sodium

Pegaptanib sodium (Macugen((R))) blocks the extracellular vascular endothelial growth factor (VEGF) isoform VEGF(165), whose elevated levels are associated with the development of choroidal neovascularization (CNV). This selective inhibition prevents binding to the VEGF receptors and the development of the increased vascular permeability and the CNV associated with neovascular age-related degen...